10 BEST DECONGESTANT SPRAYS for sale in 2025 – compare between the best decongestant sprays on sale.

Rank Product Rating
1
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist Sinus Nasal Spray Decongestant for Fast Relief of Cold and Allergy Congestion, 0.5 OZ Bottle (2 Pack = 1 OZ)
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203 Reviews
Product Highlights
  • SINUS PRESSURE RELIEF. Effective nasal spray decongestant that relieves sinus pressure and shrinks swollen nasal membranes
  • FOR COLDS AND ALLERGIES. Over-the-counter nasal spray that helps relieve the nasal stuffiness that often accompanies colds, hay fever, or upper respiratory allergies
  • STARTS WORKING INSTANTLY. Provides powerful sinus congestion relief in seconds
  • 12 HOUR RELIEF. Works for up to 12 hours for long-lasting relief of nasal stuffiness and sinus pressure

$14.97
2
Mucinex Sinus-Max Nasal Spray for Sinus & Allergy (.75 oz Bottle), Fast-Acting & Fragrance Free 12 Hour Severe Nasal Congestion Relief
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Product Highlights
  • What is it: This nasal spray (0.75 fl oz per bottle) provides targeted nasal congestion relief due to upper respiratory allergies or hay fever. Active ingredient: oxymetazoline hydrochloride 0.05%.
  • Long lasting: Lasts up to 12 hours, through the day or night.
  • Key benefits: Fast acting relief that lasts for up to 12 hours, non-drowsy and nasal congestion relief due to upper respiratory allergies or hay fever.
  • Uses: Temporarily relieves nasal congestion due to a cold, hay fever or other upper respiratory allergies. Promotes nasal & sinus drainage. Temporarily relieves sinus congestion and pressure. Helps clear nasal passages; shrinks swollen membranes.

$9.94
3
Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl; Provides 12 Hour Nasal Congestion Relief, 1 Fluid Ounce
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Product Highlights
  • ACTIVE INGREDIENT: This nasal spray contains oxymetazoline HCl, the #1 doctor recommended adult nasal spray active ingredient (of US physicians surveyed by an independent market research firm) Compare to the active ingredient in Afrin No Drip
  • SOOTHING 12 HOUR MAXIMUM STRENGTH RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides 12 hours of maximum strength nasal congestion relief due to the common cold, hay fever and upper respiratory allergies
  • FAST NASAL CONGESTION RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides fast and powerful relief for colds and allergies Temporarily relieves sinus congestion and pressure
  • NASAL RELIEF: Amazon Basic Care No Drip Nasal Spray, Oxymetazoline HCl provides temporary nasal congestion relief by shrinking swollen nasal membranes so you can breathe more freely

$4.99
4
RELIABLE 1 LABORATORIES 12 Hour Decongestant Nasal Spray (1 fl oz) (3 Pack) Oxymetazoline HCI Non Drip - Rapid & Powerful Congestion Relief
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Product Highlights
  • Compare to Afrin Original
  • Rapid & powerful anti drip congestion relief
  • 12 hour relief
  • Buy Reliable 1 Laboratories decongestant nasal spray with confidence!

$9.99
5
GoodSense Maximum Strength Nasal Spray, Fast Powerful Congestion Relief For Colds and Allergies
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Product Highlights
  • ACTIVE INGREDIENT: The active ingredient is oxymetazoline hydrochloride 0.05%, nasal decongestant, Compare to Afrin Original active ingredient.
  • PURPOSE: This original nasal spray mist temporarily relieves nasal congestion and sinus congestion and pressure due to common cold, hay fever, and upper respiratory allergies.
  • ALLERGY RELIEF AND COLD RELIEF: Nasal Spray Oxymetazoline HCl 0.05% maximum strength, provides fast, powerful congestion relief for allergies and colds for up to 12 hours.
  • UNDERSTANDING ALLERGIES: An allergy is a sensitivity to a substance that is normally harmless. Flowers, trees, a family pet, or dust are examples of things that can cause an allergy.

$3.99
6
Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray - 120 Sprays
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2,025 Reviews
Product Highlights
  • One 120-spray bottle of Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray
  • The most prescribed allergy medicine, Flonase provides nasal congestion relief and alleviates runny nose, sneezing, itchy nose and watery, itchy eyes
  • The most doctor recommended brand in allergy relief, Flonase creates an allergy shield at the source of your symptoms for unsurpassed symptom relief
  • Fluticasone propionate allergy medication controls seasonal and year-round allergy symptoms

$19.30
7
Nasacort Allergy 24HR Nasal Spray for Adults, Non-Drowsy & Alcohol-Free, 120 Sprays, 0.57 fl. oz. 2pk
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Product Highlights
  • INCLUDES: Two (2) 0.57 fl. oz. spray bottles of Nasacort Allergy 24HR Nasal Spray for Adults
  • 24-HOUR RELIEF: Nasacort Nasal Spray provides a full 24 hours of relief from nasal allergy symptoms
  • MULTI-SYMPTOM RELIEF: Nasacort Spray relieves nasal allergy congestion, sneezing, and runny and itchy nose
  • NON-DROWSY: This alcohol-free and scent-free nasal allergy spray won't make you drowsy

$37.99 $21.95
8
NeilMed SinuFrin Decongestant 0.5 Fluid Ounce (15 mL) (packaging may vary)
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Product Highlights
  • Quick nasal congestion relief
  • Relief up to 12 hours of nasal congestion
  • Oxymetazoline HCI nasal solution

$7.00
9
Xlear 12-Hour Decongestant Nasal Spray with Oxymetazoline & Xylitol, Instant Relief All-Natural Saline Nasal Spray for Severe Sinus Pressure, Congestion & Headaches (0.5 fl oz)
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Product Highlights
  • NATURAL SINUS RELIEF & NASAL RINSE: Our Non-drowsiness 12-Hour Xlear nasal spray with xylitol will gently clean and moisturize the sinus tissues with providing congestion relief. Unlike other normal saline nasal sprays our decongestant nasal saline spray acts as a nasal decongestant for severe sinus pressure and congestion by targeting the primary causes of nasal congestion. Our nose spray will help reduce tissue swelling from pollen, pollution, bacteria and all other irritants.
  • IMPROVED FORMULA WITH OXYMETAZOLINE & XYLITOL: Our patented saline nasal spray solution reduces tissue inflammation and naturally opens airways. With added oxymetazoline our nasal decongestant spray features antimicrobial and antihistamine properties to help off sickness. Xylitol's powerful oral and upper respiratory health benefits come from its unique five-carbon structure. Xylitol helps to reduce swelling and allergy symptoms by reducing bacterial adhesion on you nasal tissue.
  • SAFE NASAL RINSE & SPRAY: Our all natural nasal cleaner is safe for kids, non-addictive and Non GMO Project Verified and is effective without the use of steroids, drugs or chemicals. It’s the ideal daily sinus medicine that will reduce swelling and open your airways. Use our saline nose spray before bed to help reduce snoring.
  • FAST SINUS PRESSURE RELIEF: Our natural saline nasal spray will wash away pollutants and help to bring relief to chronic sinus infection. Use our sinus spray daily to protect and keep your nasal passages clean. Each 1.5 oz bottle delivers approx. 240 fine mist Sprays so you can find fast and quick relief.

$12.49
10
Zicam Extreme Congestion Relief No-Drip Liquid Nasal Spray with Soothing Aloe Vera, 0.5 Ounce
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Product Highlights
  • NO-DRIP NASAL SPRAY: Zicam's No Drip Liquid Nasal Spray is formulated so that it won't drip down your throat, unlike many nasal sprays. Get relief from nasal congestion or sinus pressure, without the aftertaste of many saline nasal sprays.
  • NASAL CONGESTION & SINUS RELIEF: Are nasal congestion or sinus pressure getting you down? Try Zicam's No-Drip Liquid Nasal Spray for up to 12 hours of non-drowsy relief from nasal congestion and sinus pressure due to colds or allergy symptoms.

$9.97

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